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RCAN2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12900-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16840854

  • 3313.85 SEK / 150µL
Estimated Shipment: 03-10-2022
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Description

Description

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin′s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
Specifications

Specifications

RCAN2
Polyclonal
Unconjugated
RCAN2
Calcipressin 2, CSP2, DSCR1L1, hRCN2, MCIP2, RCAN2, regulator of calcineurin 2, ZAKI 4, ZAKI4
Rabbit
Antigen Affinity Chromatography
RUO
10231, 53901
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q14206, Q9JHG2
Rcan2
RCAN2 Fusion Protein Ag3597
150 μL
Primary
Mouse, Human
Antibody
IgG
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