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RGMA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12387-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16840084

  • 3313.85 SEK / 150µL
Estimated Shipment: 05-10-2022
to see stock.

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Description

Description

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Specifications

Specifications

RGMA
Polyclonal
Unconjugated
RGMA
Repulsive guidance molecule A, RGM, RGM domain family member A, RGM domain family, member A, RGMA
Rabbit
Antigen Affinity Chromatography
RUO
244058, 308739, 56963
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
0.22 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q6PCX7, Q96B86
RGMA
RGMA Fusion Protein Ag3058
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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