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Invitrogen™ Human RIPK2, His Tag Recombinant Protein

Recombinant Protein

Brand:  Invitrogen™ PV4213

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Product Code. 11533637

  • 5970.00 SEK / 10µg

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For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

Description

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic

RIPK2 is a serine/threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
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Lot Number Certificate Type Date Catalog Number
Lot Number2410046J Certificate TypeCertificate of Analysis Date07/10/2023 Catalog NumberPV4213
Lot Number2410046G Certificate TypeCertificate of Analysis Date22/05/2023 Catalog NumberPV4213
Lot Number2410046F Certificate TypeCertificate of Analysis Date02/02/2023 Catalog NumberPV4213
Lot Number2410046E Certificate TypeCertificate of Analysis Date02/12/2022 Catalog NumberPV4213
Lot Number2410046B Certificate TypeCertificate of Analysis Date25/04/2022 Catalog NumberPV4213
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Invitrogen™ Human RIPK2, His Tag Recombinant Protein > 10 μg; Unlabeled

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