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ROCK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1395.65 SEK - 3774.95 SEK

Specifications

Antigen ROCK1
Concentration 0.39 mg/mL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16899764
View Documents
Proteintech
20247-1-AP-20UL
20 ÎĽL This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
16889764
View Documents
Proteintech
20247-1-AP-150UL
150 ÎĽL This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
Description

Description

The antibody is specific to ROCK1.

The Rho target protein, Rho-associated coiled coil-containing protein kinase (ROCK)-1 has been found to be a new Caspase-3 substrate. ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition. The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region. They are joined by a variable region that contains the Rho-binding domain. During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.
Specifications

Specifications

ROCK1
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Rabbit
Rat, Human, Mouse
P70335, Q13464, Q63644
19877, 6093, 81762
Peptide
Primary
-20°C
ROCK1
0.39 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
p160 ROCK 1, P160ROCK, PRO0435, ROCK1
ROCK1
IgG
Antigen Affinity Chromatography
Antibody
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Documents

Documents

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ROCK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

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