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RON/MST1R Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11053-1-AP-20UL

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Product Code. 16887863

  • 1645.54 SEK / 20µL

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Description

Description

Macrophage-stimulatin 1 receptor (MST1R/Ron), a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
Specifications

Specifications

RON/MST1R
Polyclonal
Unconjugated
MST1R
CD136, CDw136, MSP receptor, MST1R, p185 Ron, Protein tyrosine kinase 8, PTK8, RON
Rabbit
Antigen Affinity Chromatography
RUO
19882, 300999, 4486
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.4 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q04912, Q62190
MST1R
RON, MST1R Fusion Protein Ag1537
20 μL
Primary
Human, Rat, Mouse
Antibody
IgG
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Product Title
RON/MST1R Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated

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