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RTN1 (Isoform RTN1-C) Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1645.54 SEK - 4652.90 SEK

Specifications

Antigen RTN1 (Isoform RTN1-C)
Concentration 0.25 mg/mL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16884024
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Proteintech
15048-1-AP-20UL
20 μL
1645.54 SEK
20µL
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16874024
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Proteintech
15048-1-AP-150UL
150 μL
4652.90 SEK
150µL
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Description

Description

This antibody is raised against the full-length protein of human RTN1-C.

Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i. e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of ∽135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).
Specifications

Specifications

RTN1 (Isoform RTN1-C)
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Rabbit
Rat, Mouse, Human
Q16799, Q64548, Q8K0T0
104001, 116644, 6252
RTN1 (Isoform RTN1-C) Fusion Protein Ag7031
Primary
-20°C
RTN1
0.25 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
NSP, NSP-C, reticulon 1, RTN1, RTN1-C
RTN1
IgG
Antigen Affinity Chromatography
Antibody
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SDS
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Documents

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Product Title
RTN1 (Isoform RTN1-C) Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

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