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ACROBiosystems SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified) Product Code.: 17226560

ACROBiosystems SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)

Product Code. 17226560
500 μg, 500µg
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50 μg
500 μg
Unit Size:
500µg
50µg
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Product Code. 17226560

Brand: ACROBiosystems SPNC52Hg500ug

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This item is not returnable. View return policy

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 138.1 kDa. The protein migrates as 150-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number QHD43416.1
Molecular Weight (g/mol) 138.1 kDa
Quantity 500 μg
Source SARS-CoV-2 S protein, His Tag (SPN-C52Hg) is the ectodomain of SARS-CoV-2 S protein that contains AA Val 16 - Pro 1213 (Accession # QHD43416.1) and mutations, which have become increasingly common in SARS-CoV-2 viruses from around the world. The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag (at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively. L18F/ T20N/ P26S/ D138Y/ R190S/ K417T/ E484K/ N501Y/ D614G/ H655Y/ T1027I/ V1176F mutations were identified in the SARS-CoV-2 variant (known as variant P0.1) which emerged in the Brazil.)
Immunogen Val 16 - Pro 1213
Storage Requirements -20°C
Gene Alias Spike,S protein,Spike glycoprotein,S glycoprotein,COVID-19
Common Name S protein
Conjugate Unconjugated
Species SARS-CoV-2
Protein Tag His Tag
Buffer PBS
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Viral Proteins
Purity or Quality Grade >95% as determined by SDS-PAGE.
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ACROBiosystems SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)

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