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ACROBiosystems SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)
Brand: ACROBiosystems SPN-C52Hg-500ug
Additional Details : Weight : 0.00010kg
Description
It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 138.1 kDa. The protein migrates as 150-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| QHD43416.1 | |
| >95% as determined by SDS-PAGE. | |
| SARS-CoV-2 S protein, His Tag (SPN-C52Hg) is the ectodomain of SARS-CoV-2 S protein that contains AA Val 16 - Pro 1213 (Accession # QHD43416.1) and mutations, which have become increasingly common in SARS-CoV-2 viruses from around the world. The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag (at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively. L18F/ T20N/ P26S/ D138Y/ R190S/ K417T/ E484K/ N501Y/ D614G/ H655Y/ T1027I/ V1176F mutations were identified in the SARS-CoV-2 variant (known as variant P0.1) which emerged in the Brazil.) | |
| -20°C | |
| S protein | |
| His Tag | |
| Less than 1.0 EU / µg by the LAL method. | |
| Powder | |
| SARS-CoV-2 |
| 138.1 kDa | |
| 500 µg | |
| Val 16 - Pro 1213 | |
| Spike,S protein,Spike glycoprotein,S glycoprotein,COVID-19 | |
| Unconjugated | |
| PBS | |
| HEK293 | |
| Viral Proteins |