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Invitrogen™ SARS-CoV-2 Spike Protein S1/S2 (B.1.526) His-tag Recombinant Protein Product Code.: 17995641

Invitrogen™ SARS-CoV-2 Spike Protein S1/S2 (B.1.526) His-tag Recombinant Protein

Product Code. 17995641
100 μg, 100µg
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Quantity:
100 μg
Unit Size:
100µg
This item is not returnable. View return policy

Product Code. 17995641

Brand: Invitrogen™ RP88537

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This item is not returnable. View return policy

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. The mutations were identified in the SARS-CoV-2 varient known as B.1.526

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. SARS-CoV-2 S is 1273 amino acids long and consists of a signal peptide (amino acids 1-13) located at the N-terminus, the S1 subunit (14-685 residues), and the S2 subunit (686-1273 residues); the last two regions are responsible for receptor binding and membrane fusion, respectively. The S-ECD is the extracellular domain of the Spike protein.
TRUSTED_SUSTAINABILITY

Specifications

For Use With (Application) Control
Format Lyophilized
Formulation 20 mM tris with <0.1 μg/mL BSA, 0.01% mannitol, 0.01% Tween 80, 10% glycerol, 300 mM NaCl, 5-8% trehalose and no preservative; pH 8
Molecular Weight (g/mol) 134.34 kDa
Name SARS-CoV-2 Spike Protein S1/S2 (B0.1.526) His-tag
Purification Method SDS-PAGE
Quantity 100 μg
Regulatory Status RUO
Endotoxin Concentration <1.0 EU/μg
Gene Alias Coronavirus; COVID; Covid 19; COVID19; COVID-19; SARS; SARS Coronavirus; SARS CoV; SARS CoV2; SARS CoV-2; SARS Spike Protein; SARS-CoV2; SARS-CoV-2
Common Name SARS-CoV-2 Spike Protein S1/S2
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag His-tag
Sequence SARS-CoV-2 spike S1/S2 (Accession # YP_009724390.1), amino acids Met1-Pro1213 with L5F, T95I, D253G, S477N, E484K, D614G, A701V substitutions and a C-terminal His-tag
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System Baculovirus
Form Lyophilized
Purity or Quality Grade >90% as determined by SDS-PAGE.
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