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SCO1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12614-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16840424

  • 3313.85 SEK / 150µL
Estimated Shipment: 03-10-2022
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Description

Description

Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase.
Specifications

Specifications

SCO1
Polyclonal
Unconjugated
SCO1
SCO1, SCOD1
Rabbit
Antigen Affinity Chromatography
RUO
6341
-20°C
Liquid
Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O75880
SCO1
SCO1 Fusion Protein Ag3269
150 μL
Primary
Human
Antibody
IgG
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