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SHC Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10054-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16826203

  • 1211.96 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
Specifications

Specifications

SHC
0.31 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P29353, P98083
SH2 domain protein C1, SHC, SHC transforming protein 1, SHC transforming protein 3, SHC transforming protein A, SHC1, SHCA
Rabbit
IgG
20 μL
-20°C
Primary
20416, 6464
Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Unconjugated
SHC1
Liquid
SHC1
SHC Fusion Protein Ag0103
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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Special Offers

Special Offers