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SIGLEC H Rat anti-Mouse, Clone: eBio440c, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0333-81

Additional Details : Weight : 0.01000kg

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Product Code. 15236907

  • 600.00 SEK / 50µg


Estimated Shipment date
from Supplier 29-07-2019
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Description

Description

Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
Specifications

Specifications

Siglec H
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Liquid
Siglech
IgG2b, kappa
50 μg
4° C
Primary
233274
Flow Cytometry, Immunohistochemistry
eBio440c
Unconjugated
Siglech
Sialic Acid-Binding Immunoglobulin-Like Lectin H; SiglecH
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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