missing translation for 'onlineSavingsMsg'
Learn More

Invitrogen™ SIGLEC H Monoclonal Antibody (eBio440c), Super Bright™ 600, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen™ 63-0333-82

 View more versions of this product

Product Code. 16311414

  • 4355.00 SEK / 100µg

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Description

The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+

Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SIGLEC H
Monoclonal
0.2 mg/mL
PBS with BSA and 0.09% sodium azide; pH 7.2
0
Siglech
Affinity chromatography
RUO
233274
4°C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
eBio440c
Super Bright 600
Siglech
6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein
Rat
100 ÎĽg
Primary
Mouse
Antibody
IgG2b Îş
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title
Invitrogen™ SIGLEC H Monoclonal Antibody (eBio440c), Super Bright™ 600, eBioscience™, Invitrogen™ > 100 ÎĽg; Super Bright 600

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.