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SLP76 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12728-1-AP-150UL

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Product Code. 16880604

  • 4652.90 SEK / 150µL

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Description

Description

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and composed of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues that are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with phospho SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that phospho SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
Specifications

Specifications

SLP76
Polyclonal
Unconjugated
LCP2
LCP2, Lymphocyte cytosolic protein 2, SLP 76, SLP 76 tyrosine phosphoprotein, SLP76
Rabbit
Antigen Affinity Chromatography
RUO
155918, 16822, 3937
-20°C
Liquid
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.23 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q13094, Q60787
LCP2
SLP76 Fusion Protein Ag3432
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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SLP76 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 150 μL; Unconjugated

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