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SLP76 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 12728-1-AP-150UL
Additional Details : Weight : 0.00010kg
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DescriptionSLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and composed of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues that are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with phospho SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that phospho SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
|LCP2, Lymphocyte cytosolic protein 2, SLP 76, SLP 76 tyrosine phosphoprotein, SLP76|
|Antigen Affinity Chromatography|
|155918, 16822, 3937|
|Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|SLP76 Fusion Protein Ag3432|
|Rat, Mouse, Human|