Somatostatin, eFluor 660, clone: ICDCLS, eBioscience™

Description

Description: The monoclonal antibody ICDCLS recognizes human, mouse, and rat Somatostatin. Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or somatotrophin release-inhibiting factor (SRIF), is a peptide hormone with two active forms (14 and 28 amino acids) produced by alternative cleavage of a single preproprotein. Somatostatin is secreted by the delta cells of the islet of Langerhans in the pancreas as well as by the hypothalamus and intestine. Somatostatin has a variety of functions, such as regulating the endocrine system and affecting neurotransmission and cell proliferation. Somatostatin also inhibits the release of numerous secondary hormones, such as insulin and glucagon. Somatostatin can be used to identify medium size aspiny neurons in the striatum, cortex, and hippocampus. Expression of somatostatin is present in hyperplasia of the pancreatic islets as well as islet cell tumors such as somatostatinomas.Applications Reported: This ICDCLS antibody has been reported for use in microscopy and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.Applications Tested: This ICDCLS antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 5 μg/ml. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.eFluor™ 660 is a replacement for Alexa Fluor™ 647. eFluor™ 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.