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SPDEF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 11467-1-AP-150UL
Additional Details : Weight : 0.00010kg
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DescriptionPDEF (prostate-derived Ets factor) is a 37.5- kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate maligt potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
|PDEF, Prostate derived Ets factor, Prostate specific Ets, PSE, RP11 375E1__A.3, SPDEF|
|Antigen Affinity Chromatography|
|25803, 30051, 689210|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|SPDEF Fusion Protein Ag2020|
|Rat, Mouse, Human|