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Syk Mouse anti-Human, APC, Clone: 4D10.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-6696-42

Additional Details : Weight : 0.23750kg

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Product Code. 15558176

  • 2630.00 SEK / 100 tests


Estimated Shipment
04-12-2020
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Description

Description

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Specifications

Specifications

Syk
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P43405
Protein tyrosine kinase p72Syk
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
4D10.1
APC
SYK
Liquid
SYK
IgG2a, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
6850
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SDS
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For Research Use Only.