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T Cell Receptor Gamma/Delta Hamster, anti-Mouse, Biotin, Clone: GL3, STEMCELL Technologies

Hamster Monoclonal Antibody

Brand:  Stemcell Technologies 60104BT

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Product Code. 17199021

  • 7303.50 SEK / 500µg

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Description

Description

  • The GL3 antibody reacts with the δ chain of the murine T cell receptor γ/δ (TCRγ/δ or TCR gamma/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens
  • TCRγ/δ comprises a heterodimer (∼ 80 kDa in humans) of disulfide-linked γ and δ subunits that associates with CD3 on the cell surface
  • It is a member of the immunoglobulin superfamily
  • TCRγ/δ is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues
  • These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses
  • Once activated, they secrete effector cytokines in a subtype- and context-specific manner
  • Most γ/δ T cells are CD4-/CD8-, though some express CD8
  • The GL3 antibody recognizes an epitope in the constant region of the δ chain and can reportedly activate TCRγ/δ+ cells
Specifications

Specifications

T Cell Receptor Gamma/Delta
Monoclonal
Biotin
500 μg
Mouse
T Cells, T Cells, Other Subsets
Immunohistochemistry, Flow Cytometry, Immunofluorescence, Functional Assay, Blocking Assay
GL3
Hamster
Primary
IgG2 κ
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