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T Cell Receptor Gamma/Delta Hamster, anti-Mouse, Biotin, Clone: GL3, STEMCELL Technologies
Hamster Monoclonal Antibody
Brand: Stemcell Technologies 60104BT

This item is not returnable.
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Description
- The GL3 antibody reacts with the δ chain of the murine T cell receptor γ/δ (TCRγ/δ or TCR gamma/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens
- TCRγ/δ comprises a heterodimer (∼ 80 kDa in humans) of disulfide-linked γ and δ subunits that associates with CD3 on the cell surface
- It is a member of the immunoglobulin superfamily
- TCRγ/δ is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues
- These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses
- Once activated, they secrete effector cytokines in a subtype- and context-specific manner
- Most γ/δ T cells are CD4-/CD8-, though some express CD8
- The GL3 antibody recognizes an epitope in the constant region of the δ chain and can reportedly activate TCRγ/δ+ cells
Specifications
T Cell Receptor Gamma/Delta | |
Monoclonal | |
Biotin | |
500 μg | |
Mouse | |
T Cells, T Cells, Other Subsets |
Immunohistochemistry, Flow Cytometry, Immunofluorescence, Functional Assay, Blocking Assay | |
GL3 | |
Hamster | |
Primary | |
IgG2 κ |
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Product Title
T Cell Receptor Gamma/Delta Hamster, anti-Mouse, Biotin, Clone: GL3, STEMCELL Technologies
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