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TCR beta Armenian Hamster anti-Mouse, Functional Grade, Clone: H57-597, eBioscience™

Armenian Hamster Monoclonal Antibody

622.00 SEK - 2250.00 SEK

Specifications

Antigen TCR beta
Clone H57-597
Target Species Mouse
Conjugate Functional Grade
Isotype IgG
View More Specs

Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15218717
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Affymetrix eBioscience
16-5961-81
50 μg
622.00 SEK
50µg
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Estimated Shipment
11-01-2021
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15228717
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Affymetrix eBioscience
16-5961-82
100 μg
1268.00 SEK
100µg
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Estimated Shipment
11-01-2021
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15238717
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Affymetrix eBioscience
16-5961-85
500 μg
2250.00 SEK
500µg
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Estimated Shipment
11-01-2021
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Description

Description

001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR beta
Mouse
IgG
Monoclonal
Liquid
Antibody
4° C
H57-597
Functional Grade
Flow Cytometry, Functional Assay
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO
SDS

For Research Use Only.