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TET1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand: Invitrogen PA572805

Product Code. 15931465

4605.00 SEK / 0.10mg

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Description

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Specifications

Antigen	TET1
Classification	Polyclonal
Conjugate	Unconjugated
Gene	TET1
Gene Alias	2510010B09Rik; AA517754; bA119F7.1; BB001228; CXXC finger 6; CXXC zinc finger 6; CXXC6; CXXC-type zinc finger protein 6; D10Ertd17e; KIAA1676; LCX; leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; mKIAA1676; MLL-TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein; ten-eleven translocation 1 gene protein homolog; ten-eleven translocation-1; tet methylcytosine dioxygenase 1; tet oncogene 1; Tet1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456; TET1-MLL
Host Species	Rabbit
Purification Method	Antigen affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	309902, 52463, 80312
Content And Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form	Liquid

Applications	Immunohistochemistry (Paraffin), Western Blot
Concentration	1 mg/mL
Formulation	PBS with 0.02% sodium azide
Gene Accession No.	Q3URK3, Q8NFU7
Gene Symbols	TET1
Immunogen	TET1 antibody for an 18 amino acid peptide near the carboxy terminus of human TET1. The immunogen is within amino acids 2030 - 2080 of TET1.
Quantity	100 μg
Primary or Secondary	Primary
Target Species	Human, Mouse, Rat
Product Type	Antibody
Isotype	IgG

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TET1 Polyclonal Antibody, Invitrogen™ > 100 μg; Unconjugated

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TET1 Polyclonal Antibody, Invitrogen™

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