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TRAF3 Mouse anti-Human, Mouse, Clone: 1E3F4, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66310-1-IG-20UL
Additional Details : Weight : 0.00010kg
Description
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.Specifications
TRAF3 | |
Monoclonal | |
2 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q13114, Q60803 | |
TRAF3 | |
TRAF3 Fusion Protein Ag12185 | |
20 μL | |
Primary | |
Mouse, Human | |
Antibody | |
IgG2a |
Western Blot, Immunofluorescence, Immunocytochemistry, Immunohistochemistry (Paraffin) | |
1E3F4 | |
Unconjugated | |
TRAF3 | |
CAP 1, CAP1, CD40 binding protein, CD40bp, CRAF1, LAP1, LMP1 associated protein 1, TRAF3 | |
Mouse | |
Protein A | |
RUO | |
22031, 7187 | |
-20°C | |
Liquid |