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UNC5A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen UNC5A
Concentration 0.21 mg/mL
Applications Western Blot, Flow Cytometry
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16899754
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Proteintech
20239-1-AP-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 07-05-2024
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16889754
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Proteintech
20239-1-AP-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 07-05-2024
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Description

Description

The antibody is specific to UNC5A. It has no cross reaction to UNC5B, UNC5C and UNC5D.

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.
Specifications

Specifications

UNC5A
Western Blot, Flow Cytometry
Unconjugated
Rabbit
Human, Mouse, Rat
O08721, Q6ZN44, Q8K1S4
107448, 60629, 90249
Peptide
Primary
-20°C
UNC5A
0.21 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
KIAA1976, Netrin receptor UNC5A, Protein unc 5 homolog 1, Protein unc 5 homolog A, unc 5 homolog A (C. elegans), UNC5A, UNC5H1
Unc5a
IgG
Antigen Affinity Chromatography
Antibody
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SDS
Documents

Documents

Product Certifications