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ZO-1 Mouse anti-Canine, Human, Alexa Fluor® 488, Clone: ZO1-1A12, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA339100A488

Additional Details : Weight : 0.01000kg

Product Code. 15628028

  • 2870.00 SEK / 50µL


In stock, ready to ship: 2
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Description

Description

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Specifications

Specifications

ZO-1
Monoclonal
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
O97758, Q07157
ZO-1, ZO1
Mouse
IgG1
50 μL
4° C, store in dark, DO NOT FREEZE!
Primary
403752, 7082
Immunocytochemistry, Immunofluorescence
ZO1-1A12
Alexa Fluor™ 488
TJP1
Liquid
TJP1
Human recombit ZO-1 fusion protein encompassing amino acids 334-634
Affinity chromatography
RUO
Antibody
Monoclonal
Canine, Human
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