CAS RN 1110813-31-4

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Tocris Bioscience™ Dacomitinib

Potent irreversible pan ErbB inhibitor

Pricing and Availability
Specifications

CAS	1110813-31-4
Chemical Name or Material	(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Recommended Storage	Store at 4°C
Molecular Formula	C₂₄H₂₅ClFN₅O₂
Formula Weight	Observed MW: 469.94
Assay Percent Range	>98%

Dacomitinib, MedChemExpress

MedChemExpress Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	469.94
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Dacomitinib
Grade	Research
SMILES	O=C(/C=C/CN1CCCCC1)NC2=CC3=C(C=C2OC)N=CN=C3NC4=CC=C(C(Cl)=C4)F
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	1110813-31-4
Solubility Information	DMSO : 40 mg/mL (85.12 mM; Need ultrasonic)
Synonym	PF-00299804 PF-299804
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₅ClFN₅O₂
Formula Weight	469.94

CAS RN 1110813-31-4

CAS RN 1110813-31-4

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