CAS RN 1140964-99-3

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E7449, MedChemExpress

MedChemExpress E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ∼50 and ∼50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.

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Specifications

Molecular Weight (g/mol)	317.34
Color	Yellow
Physical Form	Solid
Chemical Name or Material	E7449
Grade	Research
SMILES	O=C1NNC2=C3C1=CC=CC3=NC(CN4CC5=C(C=CC=C5)C4)=N2
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.0%
CAS	1140964-99-3
Solubility Information	DMSO : 6.4 mg/mL (20.17 mM; Need ultrasonic and warming)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₅N₅O
Formula Weight	317.34

CAS RN 1140964-99-3

CAS RN 1140964-99-3

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