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CAS RN 1448347-49-6

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1

Tocris Bioscience™ Ivosidenib
GREENER_CHOICE

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Molekylformel C28H22ClF3N6O3
Rekommenderad förvaring Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS 1448347-49-6
Mål Isocitrate Dehydrogenase 1/IDH1
Kemiskt namn eller material (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
2

Ivosidenib, TRC

CAS: 1448347-49-6 Molekylformel: C28H22ClF3N6O3 Molekylvikt (g/mol): 582.96 Synonym: (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide,AG 120 Glycinamide, N2-[1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl]-2-(2-chlorophenyl)-N1-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-; LEDER: Fc1cncc(c1)N([C@H](C(=O)NC2CC(F)(F)C2)c3ccccc3Cl)C(=O)[C@@H]4CCC(=O)N4c5cc(ccn5)C#N

Molekylformel C28H22ClF3N6O3
CAS 1448347-49-6
LEDER Fc1cncc(c1)N([C@H](C(=O)NC2CC(F)(F)C2)c3ccccc3Cl)C(=O)[C@@H]4CCC(=O)N4c5cc(ccn5)C#N
Molekylvikt (g/mol) 582.96
Synonym (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide,AG 120 Glycinamide, N2-[1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl]-2-(2-chlorophenyl)-N1-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-;
3

Ivosidenib, MedChemExpress

MedChemExpress Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity.

ENCOMPASS_PREFERRED
Molekylformel C28H22ClF3N6O3
Rekommenderad förvaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Formel vikt 582.96
Hållbarhet Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Hälsofara 1 H315∣H317∣H319∣H335
Löslighetsinformation DMSO : ≥ 39 mg/mL (66.90 mM)
Anteckningar om renhetsgrad Research
Fysisk form Powder
Kvalitet Research
Färg White
CAS 1448347-49-6
LEDER ClC1=C([C@H](N(C2=CC(F)=CN=C2)C([C@H]3N(C4=NC=CC(C#N)=C4)C(CC3)=O)=O)C(NC5CC(F)(F)C5)=O)C=CC=C1
Molekylvikt (g/mol) 582.96
Synonym AG-120
Kemiskt namn eller material Ivosidenib
Procent renhet 98.01%
För användning med (applikation) Cancer-programmed cell death