CAS RN 1562338-42-4

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Molekylvikt (g/mol): —

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MedChemExpress Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

Prissättning och tillgänglighet
Specifikationer

Molekylformel	C₂₂H₂₇N₅O₂
Rekommenderad förvaring	4°C, sealed storage, away from moisture and light∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture and light)
Formel vikt	393.48
Hållbarhet	4°C, sealed storage, away from moisture and light∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture and light)
Löslighetsinformation	DMSO : 5 mg/mL (12.71 mM; ultrasonic and warming and heat to 80°C)
Anteckningar om renhetsgrad	Research
Fysisk form	Powder
Kvalitet	Research
Färg	Yellow
CAS	1562338-42-4
LEDER	OC1=CC(C2=CNN=C2)=CC=C1C3=CC=C(OC4CC(C)(C)NC(C)(C)C4)N=N3
Molekylvikt (g/mol)	393.48
Synonym	LMI070 NVS-SM1
Kemiskt namn eller material	Branaplam
Procent renhet	95.62%
För användning med (applikation)	Cancer-programmed cell death

CAS RN 1562338-42-4

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