CAS RN 284028-89-3
CAS RN 284028-89-3
IUPAC Namn:
2-[4-(trifluoromethyl)phenyl]-1H,4H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
Synonymer:
2-[4-(trifluoromethyl)phenyl]-1H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
Molekylvikt (g/mol):
312.31
Molekylär sammansättning:
C14H11F3N2OS
InChi Key:
KLGQSVMIPOVQAX-UHFFFAOYSA-N
SMILES:
FC(F)(F)C1=CC=C(C=C1)C1=NC(=O)C2=C(CCSC2)N1
1
–
3
av
3
Resultat
1
2
3
XAV-939, MedChemExpress
MedChemExpress XAV-939 is a potent tankyrase inhibitor that targets Wnt/β-catenin signaling. XAV-939 stabilizes axin by inhibiting tankyrase 1 and tankyrase 2 (IC50s of 5 and 2 nM, respectively), thereby stimulating β-catenin degradation. XAV939 binds tightly to the catalytic (PARP) domains of TNKS1 and TNKS2 (Kds of 99 and 93 nM, respectively).
