CAS RN 935693-62-2

IUPAC Namn: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

Synonymer: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

Molekylvikt (g/mol): 490.65

Molekylär sammansättning: C28H38N6O2

InChi Key: OSXFATOLZGZLSK-UHFFFAOYSA-N

SMILES: COC1=CC2=NC(=NC(NC3CCN(CC4=CC=CC=C4)CC3)=C2C=C1OC)N1CCCN(C)CC1

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Thermo Scientific™ BIX-01294, 95 %

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BIX-01294, MedChemExpress

MedChemExpress BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.

Prissättning och tillgänglighet
Specifikationer

Molekylformel	C₂₈H₃₈N₆O₂
Rekommenderad förvaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Formel vikt	490.64
Hållbarhet	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Hälsofara 1	H302∣H315∣H319∣H335
Löslighetsinformation	DMSO : ≥ 110 mg/mL (224.20 mM) ∣H2O : 1 mg/mL (2.04 mM; Need ultrasonic)
Anteckningar om renhetsgrad	Research
Fysisk form	Solid
Kvalitet	Research
Färg	Off-White
CAS	935693-62-2
LEDER	COC1=C(OC)C=C(C(NC2CCN(CC3=CC=CC=C3)CC2)=NC(N4CCN(C)CCC4)=N5)C5=C1
Molekylvikt (g/mol)	490.64
Kemiskt namn eller material	BIX-01294
Procent renhet	98.0%
För användning med (applikation)	Cancer-programmed cell death

CAS RN 935693-62-2

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