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BBS5 Mouse anti-Human, Mouse, Clone: 4G8E12, Proteintech

Mouse Monoclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen BBS5
Clone 4G8E12
Concentration 0.72 mg/mL
Applications Western Blot, Immunohistochemistry (Paraffin)
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16897735
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Proteintech
66136-1-IG-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 03-04-2024
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16887735
View Documents Promotion Details
Proteintech
66136-1-IG-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 03-04-2024
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Description

Description

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Specifications

Specifications

BBS5
0.72 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Bardet Biedl syndrome 5, BBS5
Bbs5
IgG1
Protein G
Antibody
4G8E12
Western Blot, Immunohistochemistry (Paraffin)
Unconjugated
Mouse
Mouse, Human
Q8N3I7, Q9CZQ9
129880, 72569
BBS5 Fusion Protein Ag6844
Primary
-20°C
BBS5
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SDS
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Documents

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