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BBS5 Mouse anti-Human, Mouse, Clone: 4G8E12, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66136-1-IG-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16887735

  • 3313.85 SEK / 150µL
Estimated Shipment: 02-12-2021

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Description

Description

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Specifications

Specifications

BBS5
4G8E12
Unconjugated
BBS5
Liquid
Bbs5
BBS5 Fusion Protein Ag6844
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
0.72 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8N3I7, Q9CZQ9
Bardet Biedl syndrome 5, BBS5
Mouse
IgG1
150 μL
-20°C
Primary
129880, 72569
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