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beta Catenin Monoclonal Antibody (15B8), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience 14-2567-95

Product Code. 17180612

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Description

The 15B8 MAb reacts with human and mouse beta-catenin, one member of a family of catenins, which are intracellular proteins that interact with cadherins to mediate cellular adhesion. More specifically, beta-catenin binds to the cytoplasmic tail of E-cadherin. In addition, this molecule is a component of the canonical Wnt signaling pathway. In the absence of Wnt binding its receptor, beta-catenin is phosphorylated and resides in the cytoplasm where it is eventually targeted for degradation by ubiquitination. Upon Wnt binding, beta-catenin becomes dephosphorylated, translocates to the nucleus, and modulates gene expression in partnership with the transcription factors T cell factor (TCF) and lymphocyte enhancer binding factor (LEF). Expression of beta-catenin is found in a wide variety of non-immune and immune tissues, including thymocytes and T and B lymphocytes. The Wnt and beta-catenin signaling pathway has been demonstrated to play a crucial role in the development of T, B, and hematopoietic stem cells.

beta Catenin Monoclonal antibody specifically detects beta Catenin in Human, Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Specifications

Antigen	beta Catenin
Classification	Monoclonal
Concentration	0.5 mg/mL
Formulation	PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.	P35222, Q02248
Host Species	Mouse
Quantity	10 mg
Primary or Secondary	Primary
Target Species	Human, Mouse
Product Type	Antibody
Isotype	IgG1 κ

Applications	Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone	15B8
Conjugate	Unconjugated
Gene	CTNNB1
Gene Alias	armadillo; Bcatenin; B-catenin; beta catenin; Betacatenin; beta-catenin; beta-catenin 1; Bfc; C20orf33; catenin; catenin (cadherin associated protein), beta 1; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein) beta 1; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; catenin beta; catenin beta 1; catenin beta 1 L homeolog; Catenin beta1; catenin beta-1; Catenin ß 1; Catenin ß1; Catnb; CHBCAT; CTNB1; CTNNB; Ctnnb1; ctnnb1.L; ctnnb1-a; ctnnb1-b; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; id:ibd2058; Mesc; MRD19; NAP; NYD-SP19; OK/SW-cl.35; OTTHUMP00000209289; P14L; PP8304; PRO2286; RP5-1118M15.1; wu:fb73e10; wu:fi81c06; wu:fk25h01; XELAEV_18031149mg; ß catenin; ßcatenin
Purification Method	Affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	12387, 1499
Content And Storage	4° C
Form	Liquid

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beta Catenin Monoclonal Antibody (15B8), eBioscience™, Invitrogen™ > 10 mg; Unconjugated

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beta Catenin Monoclonal Antibody (15B8), eBioscience™, Invitrogen™

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