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c-Cbl Mouse anti-Human, Clone: 2F6D1, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66576-1-IG-20UL
Additional Details : Weight : 0.00010kg
Description
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.Specifications
| c-Cbl | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P22681 | |
| CBL | |
| c-Cbl Fusion Protein Ag23033 | |
| 20 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| 2F6D1 | |
| Unconjugated | |
| CBL | |
| C CBL, CBL, CBL2, c-Cbl, Proto oncogene c Cbl, RING finger protein 55, RNF55 | |
| Mouse | |
| Protein G | |
| RUO | |
| 867 | |
| -20°C | |
| Liquid |