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CD71 (Transferrin Receptor) Mouse, anti-Human, APC, Clone: OKT9, STEMCELL Technologies
Mouse Monoclonal Antibody
Brand: Stemcell Technologies 60106AZ
Additional Details : Weight : 0.00110kg
Description
- The OKT9 antibody reacts with CD71 (transferrin receptor), an ∼180 - 190 kDa disulfide-bonded homodimer and type 2 transmembrane glycoprotein expressed at high levels on a broad range of actively proliferating cells, as well as reticulocytes, monocytes, macrophages and marrow stromal cells
- Surface levels are low on resting leukocytes but are upregulated on lymphocytes, monocytes and macrophages following antigen or mitogen stimulation
- Expression is lost during differentiation of reticulocytes into mature erythrocytes
- CD71 mediates uptake of transferrin–iron complexes through receptor-mediated endocytosis and recycling of the apotransferrin–receptor complex to the cell surface
- It has also served as a target for drug delivery
- The OKT9 antibody binds an epitope that reportedly overlaps with that of antibody clone CY1G4 but is distinct from the ligand binding site for transferrin
Specifications
| CD71 (Transferrin Receptor) | |
| Monoclonal | |
| APC | |
| 100 Tests | |
| Human | |
| Erythroid Cells |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| OKT9 | |
| Mouse | |
| Primary | |
| IgG1 κ |