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Doxorubicin hydrochloride, Thermo Scientific™
Doxorubicin hydrochloride, CAS # 25316-40-9, is the hydrochloride salt of doxorubicin, isolated from the bacterium Streptomyces peucetius, and is considered to be an anthracycline antibiotic with antineoplastic activity.
2397.65 SEK - 5284.65 SEK
Kemiska identifierare
| CAS | 25316-40-9 |
|---|---|
| Molekylformel | C27H30ClNO11 |
| Molekylvikt (g/mol) | 579.98 |
| MDL-nummer | MFCD00077757,MFCD00077757,MFCD00941448 |
| InChI-nyckel | MWWSFMDVAYGXBV-FGBJBKNOSA-N |
| Synonym | doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs |
| PubChem CID | 129626538 |
| IUPAC-namn | hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride |
| LEDER | [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O |
| Produktkod | Brand | Kvantitet | Pris | Kvantitet och tillgänglighet | |||||
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| Produktkod | Brand | Kvantitet | Pris | Kvantitet och tillgänglighet | |||||
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15476139
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Thermo Scientific Alfa Aesar
J64000.MA |
10mg |
 2670.70 SEK 2397.65 SEK / 10mg Save 273.05 SEK 10% Av |
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15486139
|
Thermo Scientific Alfa Aesar
J64000.MF |
50mg |
5886.67 SEK 5284.65 SEK / 50mg Save 602.02 SEK 10% Av |
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Description
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
- Doxorubicin hydrochloride, isolated from the bacterium Streptomyces peucetius, is an anthracycline antibiotic with antineoplastic activity and is related to daunorubicin
- It can intercalate between base pairs in the DNA helix preventing DNA replication
- It also inhibits the nucleic acid synthesis and can induce apoptosis
- It can inhibit DNA topoisomerase II, resulting in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication, and prevents nucleotide strand ligation after double-strand breakage
- Doxorubicin hydrochloride forms oxygen free radicals that result in cytotoxicity and lead to the lipid peroxidation of cell membrane lipids
Application
- This compound displays a fluorescent property allowing the measurement of drug efflux pump activity and examining the role of subcellular organelles (Golgi complex and lysosome) in the sequestration of drugs
- It has been used in cell viability assays
- It is used as a drug in polymeric PLGA-based microparticulate drug delivery and to develop in vitro doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)
- It is a substrate of the MRP1 transporter
Chemical Identifiers
| 25316-40-9 | |
| 579.98 | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| 129626538 | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O |
| C27H30ClNO11 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride |
Specifications
| Doxorubicin hydrochloride | |
| C27H30ClNO11 | |
| 4229251 | |
| doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs | |
| MWWSFMDVAYGXBV-FGBJBKNOSA-N | |
| hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride | |
| 129626538 |
| 25316-40-9 | |
| MFCD00077757,MFCD00077757,MFCD00941448 | |
| 14,3439 | |
| Soluble in water. | |
| [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O | |
| 579.98 | |
| 579.99 |
Safety and Handling
GHS H Statement
H350-H302
May cause cancer.
Harmful if swallowed.
P201-P202-P261-P264b-P270-P271-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P330-P332+P313-P362-P501c
H302-H315-H318-H335-H340-H350-H361fd
missing translation for 'einecsNumber' : 246-818-3
missing translation for 'rtecsNumber' : QI9295900
missing translation for 'tsca' : No
Recommended Storage : Ambient temperatures
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Doxorubicin hydrochloride
Signal Word
- Fara
Hazard Category
- Akut toxicitet Kategorija 4
- Allvarlig ögonskada/ögonirritation Kategorija 1
- Mutagenitet i könsceller Kategorija 1A
- Reproduktionstoxicitet Kategorija 2
- Frätande eller irriterande verkan på hud Kategori 2
- Specifik organtoxicitet Kategorija 3
Hazard Statement
- H302-Skadligt vid förtäring.
- H315-Irriterar huden.
- H318-Orsakar allvarliga ögonskador.
- H335-Kan orsaka irritation i luftvägarna.
- H340-Kan orsaka genetiska defekter.
- H361fd-Misstänks kunna skada fertiliteten. Misstänks kunna skada det ofödda barnet.
Precautionary Statement
- P280-Använd skyddshandskar/skyddskläder/ögonskydd/ansiktsskydd.
- P301+P330+P331-VID FÖRTÄRING: Skölj munnen. Framkalla INTE kräkning.
- P302+P352-VID HUDKONTAKT: Tvätta med mycket vatten/.
- P304+P340-VID INANDNING: Flytta personen till frisk luft och se till att andningen underlättas.
- P305+P351+P338-VID KONTAKT MED ÖGONEN: Skölj försiktigt med vatten i flera minuter. Ta ur eventuella kontaktlinser om det går lätt. Fortsätt att skölja.
- P310-Kontakta genast GIFTINFORMATIONSCENTRALEN/läkare .
- P332+P313-Vid hudirritation: Sök läkarhjälp.
Supplemental information
- MIXTURE LIST-Contain: Doxorubicin hydrochloride
RUO – Research Use Only
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