missing translation for 'onlineSavingsMsg'
Learn More

Factor XIIIa Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 17223-1-AP-20UL

Additional Details : Weight : 0.00010kg

 View more versions of this product

Product Code. 16887074

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

Please to purchase this item. Need a web account? Register with us today!


Description

Description

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Specifications

Specifications

Factor XIIIa
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O08619, P00488, Q8BH61
Coagulation factor XIIIa, F13A, F13A1, Transglutaminase A chain
Rabbit
IgG
20 μL
-20°C
Primary
2162, 60327, 74145
Western Blot
Unconjugated
F13A1
Liquid
F13a1
Factor XIIIa Fusion Protein Ag11059
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Rat, Mouse
Videos
SDS
missing translation for 'documents'
Product Certifications
Special Offers

Special Offers