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IRF8 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 24437-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
This antibody specifically recognizes the 48 kDa IRF8 protein.
IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.Specifications
IRF8 | |
Polyclonal | |
Unconjugated | |
IRF8 | |
H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
3394 | |
-20°C | |
Liquid |
Western Blot | |
0.34 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q02556 | |
IRF8 | |
IRF8 Fusion Protein Ag19909 | |
20 μL | |
Primary | |
Human | |
Antibody | |
IgG |