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IRF8 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 24437-1-AP-20UL

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Product Code. 16882915

  • 1645.54 SEK / 20µL

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Description

Description

This antibody specifically recognizes the 48 kDa IRF8 protein.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
Specifications

Specifications

IRF8
Polyclonal
Unconjugated
IRF8
H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8
Rabbit
Antigen Affinity Chromatography
RUO
3394
-20°C
Liquid
Western Blot
0.34 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q02556
IRF8
IRF8 Fusion Protein Ag19909
20 μL
Primary
Human
Antibody
IgG
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IRF8 Rabbit anti-Human, Polyclonal, Proteintech > 20 μL; Unconjugated

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