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JIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 14568-1-AP-20UL
Additional Details : Weight : 0.00010kg
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DescriptionThe protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
|IB 1, IB1, Islet brain 1, JIP 1, JIP1, JNK interacting protein 1, MAPK8IP1, PRKM8IP|
|Antigen Affinity Chromatography|
|116457, 19099, 9479|
|Immunofluorescence, Immunocytochemistry, Western Blot, Immunohistochemistry (Paraffin)|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q9R237, Q9UQF2, Q9WVI9|
|JIP1 Fusion Protein Ag6150|
|Human, Rat, Mouse|