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JIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand: Proteintech 14568-1-AP-20UL

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Product Code. 16883264

1645.54 SEK / 20µL

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Description

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Specifications

Antigen	JIP1
Classification	Polyclonal
Conjugate	Unconjugated
Gene	MAPK8IP1
Gene Alias	IB 1, IB1, Islet brain 1, JIP 1, JIP1, JNK interacting protein 1, MAPK8IP1, PRKM8IP
Host Species	Rabbit
Purification Method	Antigen Affinity Chromatography
Regulatory Status	RUO
Gene ID (Entrez)	116457, 19099, 9479
Content And Storage	-20°C
Form	Liquid

Applications	Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunofluorescence
Concentration	0.3 mg/mL
Formulation	PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.	Q9R237, Q9UQF2, Q9WVI9
Gene Symbols	Mapk8ip1
Immunogen	JIP1 Fusion Protein Ag6150
Quantity	20 μL
Primary or Secondary	Primary
Target Species	Mouse, Rat, Human
Product Type	Antibody
Isotype	IgG

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JIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated

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JIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

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