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MYH9 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11128-1-AP-20UL

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Product Code. 16887993

  • 1645.54 SEK / 20µL

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Description

Description

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer′s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
Specifications

Specifications

MYH9
Polyclonal
Unconjugated
MYH9
MYH9, Myosin 9, Myosin heavy chain 9, myosin IIa, Nonmuscle myosin IIa
Rabbit
Antigen Affinity Chromatography
RUO
100911597, 17886, 333938, 4627
-20°C
Liquid
Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot
0.19 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P35579, Q62812, Q8VDD5
Myh9, myh9a
MYH9 Fusion Protein Ag1612
20 ÎĽL
Primary
Rat, Human, Zebrafish, Mouse
Antibody
IgG
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Product Title
MYH9 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech > 20 ÎĽL; Unconjugated

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