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MYH9 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11128-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16877993

  • 3313.85 SEK / 150µL
Estimated Shipment: 08-12-2021

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Description

Description

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer′s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
Specifications

Specifications

MYH9
0.19 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P35579, Q62812, Q8VDD5
MYH9, Myosin 9, Myosin heavy chain 9, myosin IIa, Nonmuscle myosin IIa
Rabbit
IgG
150 μL
-20°C
Primary
100911597, 17886, 333938, 4627
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
MYH9
Liquid
Myh9, myh9a
MYH9 Fusion Protein Ag1612
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat, Zebrafish
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