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NRG1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2C6D12, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66492-1-IG-20UL

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Product Code. 16888415

  • 1645.54 SEK / 20µL

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Description

Description

The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.
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Product Title
NRG1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2C6D12, Proteintech > 20 ÎĽL; Unconjugated

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