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PELI1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 12053-1-AP-150UL
Additional Details : Weight : 0.00010kg
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This antibody may cross react with Pellino-3.The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
|PELI1, Pellino 1, pellino homolog 1 (Drosophila), PRISM, Protein pellino homolog 1|
|Antigen Affinity Chromatography|
|305549, 57162, 67245|
|Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|PELI1 Fusion Protein Ag2683|
|Rat, Mouse, Human|