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PrP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 12555-1-AP-150UL
Additional Details : Weight : 0.00010kg
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DescriptionHuman prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
|ASCR, CD230, CJD, GSS, Major prion protein, prion, prion protein, PRIP, PRNP, PrP, PrP27 30, PrP33 35C, PrPc|
|Antigen Affinity Chromatography|
|19122, 24686, 5621|
|Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Flow Cytometry|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|F7VJQ1, P04925, P13852|
|PrP Fusion Protein Ag3257|
|Rat, Mouse, Human|