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RIP3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 17563-1-AP-150UL
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Description
RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.Specifications
| RIP3 | |
| Polyclonal | |
| Unconjugated | |
| RIPK3 | |
| Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 11035, 56532 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 0.17 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q9QZL0, Q9Y572 | |
| Ripk3 | |
| RIP3 Fusion Protein Ag11759 | |
| 150 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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Product Title
RIP3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech > 150 μL; Unconjugated
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