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RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20129-1-AP-20UL
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Description
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ′Lys-9′ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.Specifications
RRP8 | |
Polyclonal | |
Unconjugated | |
RRP8 | |
Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
101867, 23378, 308911 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence | |
0.5 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
O43159, Q5U4F0, Q9DB85 | |
Rrp8 | |
RRP8 Fusion Protein Ag13994 | |
20 μL | |
Primary | |
Rat, Human, Mouse | |
Antibody | |
IgG |
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Product Title
RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated
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