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RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20129-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ′Lys-9′ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.Specifications
| RRP8 | |
| Polyclonal | |
| Unconjugated | |
| RRP8 | |
| Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 101867, 23378, 308911 | |
| -20°C | |
| Liquid |
| Immunofluorescence, Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.5 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O43159, Q5U4F0, Q9DB85 | |
| Rrp8 | |
| RRP8 Fusion Protein Ag13994 | |
| 20 μL | |
| Primary | |
| Mouse, Human, Rat | |
| Antibody | |
| IgG |