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RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 20129-1-AP-20UL

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Product Code. 16879624

  • 1645.54 SEK / 20µL

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Description

Description

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ′Lys-9′ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Specifications

Specifications

RRP8
Polyclonal
Unconjugated
RRP8
Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8
Rabbit
Antigen Affinity Chromatography
RUO
101867, 23378, 308911
-20°C
Liquid
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence
0.5 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O43159, Q5U4F0, Q9DB85
Rrp8
RRP8 Fusion Protein Ag13994
20 μL
Primary
Rat, Human, Mouse
Antibody
IgG
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Product Title
RRP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated

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