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RTN1 (Isoform RTN1-C) Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 15048-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
This antibody is raised against the full-length protein of human RTN1-C.
Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i. e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of ∽135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).Specifications
RTN1 (Isoform RTN1-C) | |
Polyclonal | |
Unconjugated | |
RTN1 | |
NSP, NSP-C, reticulon 1, RTN1, RTN1-C | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
104001, 116644, 6252 | |
-20°C | |
Liquid |
Western Blot, Immunohistochemistry (Paraffin) | |
0.25 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q16799, Q64548, Q8K0T0 | |
RTN1 | |
RTN1 (Isoform RTN1-C) Fusion Protein Ag7031 | |
20 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |