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Securin / PTTG1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 18040-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16888074

  • 3313.85 SEK / 150µL
Estimated Shipment: 08-12-2021

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Description

Description

Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG′s transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-Myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycle dependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, is disrupted when a DNA double-strand breaks occurs.
Specifications

Specifications

Securin / PTTG1
0.38 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O95997, P97613, Q9CQJ7
EAP1, Esp1 associated protein, HPTTG, pituitary tumor transforming 1, PTTG, PTTG1, Securin, Tumor transforming protein 1, TUTR1
Rabbit
IgG
150 μL
-20°C
Primary
30939, 64193, 9232
Immunocytochemistry, Immunofluorescence
Unconjugated
PTTG1
Liquid
Pttg1
Securin / PTTG1 Fusion Protein Ag12670
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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