missing translation for 'onlineSavingsMsg'
Learn More

TYMS Mouse anti-Human, Clone: 1F5B7, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66725-1-IG-20UL

Additional Details : Weight : 0.00010kg

 View more versions of this product

Product Code. 16828875

  • 1236.20 SEK / 20µL
Estimated Shipment: 30-11-2021

Please to purchase this item. Need a web account? Register with us today!


Description

Description

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Specifications

Specifications

TYMS
1F5B7
Unconjugated
TYMS
Liquid
TYMS
TYMS Fusion Protein Ag7027
Protein G
RUO
Antibody
Monoclonal
Human
Western Blot, Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P04818
HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS
Mouse
IgG1
20 μL
-20°C
Primary
7298
Videos
SDS
Documents
Certificates
Special Offers

Special Offers