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TYMS Mouse anti-Human, Clone: 1F5B7, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66725-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828875

  • 1656.73 SEK / 20µL
Estimated Shipment: 02-04-2024
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Description

Description

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Specifications

Specifications

TYMS
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P04818
TYMS
TYMS Fusion Protein Ag7027
20 μL
Primary
Human
Antibody
IgG1
Western Blot, Immunohistochemistry (Paraffin)
1F5B7
Unconjugated
TYMS
HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS
Mouse
Protein G
RUO
7298
-20°C
Liquid
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