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TYMS Mouse anti-Human, Clone: 1F5B7, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66725-1-IG-20UL
Additional Details : Weight : 0.00010kg
Description
Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Specifications
| TYMS | |
| 1F5B7 | |
| Unconjugated | |
| TYMS | |
| Liquid | |
| TYMS | |
| TYMS Fusion Protein Ag7027 | |
| Protein G | |
| RUO | |
| Antibody | |
| Monoclonal | |
| Human |
| Western Blot, Immunohistochemistry (Paraffin) | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P04818 | |
| HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS | |
| Mouse | |
| IgG1 | |
| 20 μL | |
| -20°C | |
| Primary | |
| 7298 |