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UNC5A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20239-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
The antibody is specific to UNC5A. It has no cross reaction to UNC5B, UNC5C and UNC5D.
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.Specifications
UNC5A | |
Polyclonal | |
Unconjugated | |
UNC5A | |
KIAA1976, Netrin receptor UNC5A, Protein unc 5 homolog 1, Protein unc 5 homolog A, unc 5 homolog A (C. elegans), UNC5A, UNC5H1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
107448, 60629, 90249 | |
-20°C | |
Liquid |
Western Blot, Flow Cytometry | |
0.21 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
O08721, Q6ZN44, Q8K1S4 | |
Unc5a | |
Peptide | |
150 μL | |
Primary | |
Rat, Mouse, Human | |
Antibody | |
IgG |