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UPF3B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 23301-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16882275

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
Specifications

Specifications

UPF3B
0.61 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BZI7
HUPF3B, hUpf3p X, MRXS14, RENT3B, UPF3B, UPF3X
Rabbit
IgG
20 μL
-20°C
Primary
313449, 65109, 68134
Western Blot, Immunohistochemistry (Paraffin)
Unconjugated
UPF3B
Liquid
Upf3b
UPF3B Fusion Protein Ag18568
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Rat, Human
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