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USP5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10473-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.Specifications
| USP5 | |
| Polyclonal | |
| Unconjugated | |
| USP5 | |
| Deubiquitinating enzyme 5, Isopeptidase T, ISOT, Ubiquitin thiolesterase 5, USP5 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 22225, 297593, 8078 | |
| -20°C | |
| Liquid |
| Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation | |
| 0.4 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P45974, P56399 | |
| USP5 | |
| USP5 Fusion Protein Ag0770 | |
| 20 μL | |
| Primary | |
| Rat, Mouse, Human | |
| Antibody | |
| IgG |